Analysis of p16_{<i>CDKN2A</i>} Methylation and HPV-16 Infection in Oral Mucosal Dysplasia

Analysis of p16(CDKN2A) methylation and HPV-16 infection in oral mucosal dysplasia.

OBJECTIVE The purpose of this study was to investigate the relationship between p16(CDKN2A) methylation and epithelial dysplasia (ED). We also evaluated the expressions of proteins related to methylation (DNMT3B and DNMT1). Finally, we tested whether HPV-16/18 or the dmt3b (C46359T) polymorphism is associated with p16(CDKN2A) methylation status. METHODS To test the hypothesis, a case-control ...

Tobacco use and oral HPV-16 infection.

Oral human papillomavirus type16 (HPV16), a sexually transmitted infection, is believed to be responsible for the rise in incidence of oropharyngeal squamous cell cancers in the United States.1 An association between self-reported number of cigarettes currently smoked per day and oral HPV prevalence has been observed.2,3 We investigated associations between objective biomarkers reflective of al...

the stady and analysis of rice agroclimatology in lenjan

the west of esfahan province, iran, is one of the most important agricultural areas throughout the country due to the climate variability and life-giving water of zayanderood river. rice is one of the major and economic crops in this area. the most important climatic elements in agricultural activities which should be considered include temperature, relative humidity, precipitation and wind. so...

More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population

BACKGROUND We have previously shown the high prevalence of oral anti-human papillomavirus type 16 (HPV-16) antibodies in women with HPV-associated cervical neoplasia. It was postulated that the HPV antibodies were initiated after HPV antigenic stimulation at the cervix via the common mucosal immune system. The present study aimed to further evaluate the effectiveness of oral fluid testing for d...

HPV infection and oral carcinogenesis.